Comparing Rheumatoid and Osteoarthritis

Comparing Rheumatoid and Osteoarthritis
Osteoarthritis	Rheumatoid
Degenerative disease	Autoimmune disease
Cartilage loss	Inflamed synovium
Morning stiffness < 30 mins	Morning stiffness > 60 mins
Asymmetrical	Symmetrical
Joints involved	Joints + Extra-articular manifestations
Age onset 20-40	Age onset > 50
Common in men and women	Commoner in women
Lack of systemic symptoms. Joint symptoms	Fatigue, low grade fever, malaise, rheumatoid nodules, sjogrens syndrome, felty's syndrome
Movement worsens pain	Movement can ease pain
PIP and DIP. Symmetrical Small and large joints	PIP and MCP and weight bearing joints - knees, hips, spine
RF negative	RF positive high CRP ESR ANA positive Anti CCP
Onset slow over years	Onset over weeks and months
Joints enlarged, cool, hard on palpation	Joints are swollen, red, warm, tender, soft synovium
Crepitus and reduced range of motion, joint malalignment	Synovitis, joint destruction
Osteophytes and joint space narrowing on X Ray	Erosions on X ray