|Herpes Varicella-Zoster (Shingles) Infection
|Chickenpox Varicella Infection
|Varicella Cerebral Vasculopathy
|Herpes Zoster Ophthalmicus (HZO) Shingles
|Rubella (German Measles)
|Epstein-Barr Virus infection
| Cytomegalovirus (CMV) infections
| CMV retinitis infections
Prescribing and dosing only by those familiar with the drug. Generally used for induction and maintenance therapy of cytomegalovirus (CMV) retinitis in patients with AIDS.
- Great care taken in those with renal failure
- Antiviral medication
Mode of action
- A pyrophosphate analog DNA polymerase inhibitor.
- CMV retinitis in AIDS: Foscarnet intermittent infusions every 8 hours at a dose of 60 mg/kg in patients with normal renal function.
- Dosage must be individualised for the patient's renal function (see dosing chart below).
- Induction therapy of mucocutaneous HSV infections unresponsive to Aciclovir: Foscavir is administered for 2-3 weeks or until healing of lesions, as intermittent infusions at a dose of 40 mg/kg over one hour every 8 hours in patients with normal renal function.
Dose Range: Needs expert dosing and monitoring
|Foscarnet||60 mg/kg ||8-hourly||IV infusion over at least one hour for 2-3 weeks|
|Foscarnet||90 mg/kg ||12-hourly||IV infusion over at least one hour for 2-3 weeks|
|Foscarnet||60-120 mg/kg/day ||Daily||IV infusion over at least one hour Maintenance|
|Name||Mucocutaneous HSV infection |
unresponsive to 10 days of IV Aciclovir
in Immunocompromised patient
|Foscarnet||40 mg/kg||8-hourly||IV infusion over at least one hour for 2-3 weeks|
- Cautions with other nephrotoxic drugs - additive toxicity may occur when used in combination with other nephrotoxic drugs
- Such as aminoglycosides, amphotericin B, Ciclosporin A, aciclovir, methotrexate and tacrolimus
- Caution: Do not administer Foscavir by rapid intravenous injection.
- Renal toxicity can be reduced by adequate hydration of the patient.
- It is recommended to establish diuresis by hydration with 0.5-1.0 litre of normal saline at each infusion.
- In compliant patients, oral hydration with similar hydration regimens have been used.
- Clinically dehydrated patients should have their condition corrected before initiating therapy.
- Dehydration, Hypersensitivity to the active substance
- Cautions in Renal failure
- Nephrotoxicity, pancytopenia, marrow depression watch FBC and symptoms
- Sepsis, Diabetes Insipidus, ataxia, neuropathy