Antituberculous drugs must be used in combination otherwise resistance occurs rapidly
- GABA transaminase inhibitor and an antibiotic, used to treat tuberculosis.
Mode of action
- Broad spectrum antibiotic Inhibits peptidoglycan synthesis
- Inhibits cell wall synthesis in susceptible strains of Gram-positive and Gram-negative bacteria and in Mycobacterium tuberculosis.
- Active pulmonary and extra-pulmonary tuberculosis: Cycloserine 500 mg to 1 g daily in divided doses, monitored by blood level determinations. The initial adult dosage most frequently given is 250 mg BD for the first two weeks. A daily dosage of 1g should not be exceeded.
The elderly: as for adults but reduce dosage if renal function is impaired.
- Klebsiella/Enterobacter species and Escherichia coli UTI:
- Epilepsy; depression, severe anxiety or psychosis; severe renal insufficiency; alcohol abuse.
- Acute porphyria: clinical exacerbations of porphyria