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1. Cancer patients need a dental check before treatment, or as soon as possible after starting treatment, to avoid osteonecrosis of the jaw.
2. Atypical femoral fractures are rare but have been reported with prolonged bisphosphonate treatment for osteoporosis. Review risks and benefits after 5 or more years of use.
|Zoledronic acid (Osteoporosis)
|IV Infusion. Give 50,000-125,000 units of vitamin D before first dose
|Zoledronic acid (Paget's)
|IV Infusion. Give 10 days of 500 mg elemental calcium twice daily (with vitamin D) prior
|Zoledronic acid (Hypercalcaemia with malignancy)
|4 mg in 100 ml NaCl 0.9% over 15 minutes