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Prothrombin time and Coagulation

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Version Jan 2023

PT result APTT result Common condition present
Prolonged Normal Liver disease, decreased Vitamin K, decreased or defective factor VII
Normal Prolonged Hemophilia A or B (decreased or defective factor VIII or IX) or factor XI deficiency, von Willebrand disease, factor XII deficiency, or lupus anticoagulant present
Prolonged Prolonged Decreased or defective factor I (fibrinogen), II (prothrombin), V or X, severe liver disease, disseminated intravascular coagulation (DIC)
Normal Normal or slightly prolonged
May indicate normal haemostasis; however, PT and PTT can be normal in conditions such as mild deficiencies in other factors and mild form of von Willebrand disease. Further testing may be required to diagnose these conditions.

PT result	APTT result	Common condition present
Prolonged	Normal	Liver disease, decreased Vitamin K, decreased or defective factor VII
Normal	Prolonged	Hemophilia A or B (decreased or defective factor VIII or IX) or factor XI deficiency, von Willebrand disease, factor XII deficiency, or lupus anticoagulant present
Prolonged	Prolonged	Decreased or defective factor I (fibrinogen), II (prothrombin), V or X, severe liver disease, disseminated intravascular coagulation (DIC)
Normal	Normal or slightly prolonged	May indicate normal haemostasis; however, PT and PTT can be normal in conditions such as mild deficiencies in other factors and mild form of von Willebrand disease. Further testing may be required to diagnose these conditions.

Prothrombin time

PT test evaluates VII, X, V, II, and I (fibrinogen).
PT tests coagulation factors in the extrinsic and common pathways of the coagulation cascade

Prolonged Prothrombin time

Liver disease,vitamin K deficiency,Warfarin/Coumadin
DIC, decreased or defective factor VII

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