Gentamicin is toxic to cochlear hair cells, and it is known to disrupt mitochondrial protein
synthesis, which leads to increased oxygen free radical generation via inducible nitric oxide
synthase activity. Please note that the maximum dose in patients >65 years of age, regardless of renal
function, is 3mg/kg.
About : Always check the BNF link here
Mode of action
Indications
Ineffective
Dose: Any total daily dose over 480 mg needs specialist advice
More information on Dosing
Dose range:You must check with BNF or drug datasheet
Name Starting Dose Frequency Route Gentamicin (Standard Indications*) 5-7 mg/kg/day with Trough < 2 mg/litre.
once daily or less dose regimen IV Gentamicin (Standard indications*) 3-5 mg/kg/day 8 hourly multiple daily dose regimen IV Gentamicin (Enterococcal Endocarditis) 1 mg/kg 8-12 hourly IV Gentamicin (Streptococcal Endocarditis) 3 mg/kg 24 hourly IV Gentamicin (Gram positive/HACEK Endocarditis) 1 mg/kg 12 hourly IV Gentamicin (Acute pyelonephritis (once daily dose regimen),
Urinary tract infection (catheter-associated, once daily dose regimen)) 5-7 mg/kg/day Once daily dosing regimen IV Notes
Multiple daily dose regimens
Once daily dose regimens
Prescribing
First dose: Follow local guidance
CrCl (ml/min) Under 40 kg 40-49 kg 50-59 kg 60-69 kg 70-79 kg Over 80 kg
<21 2.5 mg/kg (max 180 mg) then take a sample after 24 hours
21-30 Give 5 mg/kg 180 mg every 48 hrs 200 mg every 48 hrs 240 mg every 48 hrs 240 mg every 48 hrs 260 mg every 48 hrs
31-40 Give 5 mg/kg 200 mg every 48 hrs 240 mg every 48 hrs 280 mg every 48 hrs 300 mg every 48 hrs 320 mg every 48 hrs
41-50 Give 5 mg/kg 240 mg every 48 hrs 280 mg every 48 hrs 320 mg every 48 hrs 360 mg every 48 hrs 400 mg every 48 hrs
51-60 Give 5 mg/kg 200 mg every 24 hrs 240 mg every 24 hrs 280 mg every 24 hrs 300 mg every 24 hrs 320 mg every 24 hrs
Over 60 Give 5 mg/kg 240 mg every 24 hrs 280 mg every 24 hrs 320 mg every 24 hrs 360 mg every 24 hrs 400 mg every 24 hrs
Side effects
Monitoring
Interactions
Cautions
Contraindications
Side effects
Renal
References
MEDICAL DISCLAIMER:The contents are under continuing development and improvements and despite all efforts may contain errors of omission or fact. This is not to be used for the assessment, diagnosis or management of patients. It should not be regarded as medical advice by healthcare workers or laypeople. It is for educational purposes only. Please adhere to your local protocols. Use the BNF for drug information. If you are unwell please seek urgent healthcare advice. If you do not accept this then please do not use the website. Makindo Ltd |
Gentamicin
-
| About | Anaesthetics and Critical Care | Anatomy | Basic Science | Biochemistry | Cardiology | Cases | Clinical Cases | Crib | Dentistry | Dermatology | Differentials | Drugs | ENT | Electrocardiogram | Embryology | Emergency Medicine | Endocrinology | Ethics | Foundation Doctors | Gastroenterology | General Information | General Practice | Genetics | Geriatric Medicine | Guidelines | Haematology | Hepatology | Immunology | Infectious Disease | Infectious Diseases | Infographic | Investigations | Lists | Microbiology | Miscellaneous | Nephrology | Neuroanatomy | Neurology | Nutrition | OSCE | Obstetrics Gynaecology | Oncology | Ophthalmology | Oral Medicine | Paediatrics | Palliative | Pathology | Pharmacology | Physiology | Procedures | Psychiatry | Radiology | Research | Respiratory | Resuscitation | Rheumatology | Statistics | Stroke | Surgery | Surgical | Toxicology | Trauma and Orthopaedics | Twitter | Urology | Version Jan 2023