Hyperacute Due to ABO and HLA incompatibility due to existence of antibodies against transplant antigens and should never happen. Thrombosis, complement activation and organ failure immediately intra operatively. Acute: Before 3 months, worsening renal function, fever, localised pain. Biopsy done (easier as kidney in pelvis) . Give steroids, OKT3, Anti thymocyte globulin. Responds to increased immunosuppression. Acute rejection is mainly T cell mediated which is the focus of the immunosuppressive drugs Chronic: After 3 months, fibrosis and inflammatory cells. Does not respond to immunosuppression. The differential is Ciclosporin nephrotoxicity which causes raised creatinine and may warrant a renal biopsy.
|MEDICAL DISCLAIMER:The contents are under continuing development and improvements and despite all efforts may contain errors of omission or fact. This is not to be used for the assessment, diagnosis or management of patients. It should not be regarded as medical advice by healthcare workers or laypeople. It is for educational purposes only. Please adhere to your local protocols. Use the BNF for drug information. If you are unwell please seek urgent healthcare advice. If you do not accept this then please do not use the website. Makindo Ltd|
Transplant and organ rejection
| About | Anaesthetics and Critical Care | Anatomy | Basic Science | Biochemistry | Cardiology | Cases | Clinical Cases | Crib | Dentistry | Dermatology | Differentials | Drugs | ENT | Electrocardiogram | Embryology | Emergency Medicine | Endocrinology | Ethics | Foundation Doctors | Gastroenterology | General Information | General Practice | Genetics | Geriatric Medicine | Guidelines | Haematology | Hepatology | Immunology | Infectious Disease | Infectious Diseases | Infographic | Investigations | Lists | Microbiology | Miscellaneous | Nephrology | Neuroanatomy | Neurology | Nutrition | OSCE | Obstetrics Gynaecology | Oncology | Ophthalmology | Oral Medicine | Paediatrics | Palliative | Pathology | Pharmacology | Physiology | Procedures | Psychiatry | Radiology | Research | Respiratory | Resuscitation | Rheumatology | Statistics | Stroke | Surgery | Surgical | Toxicology | Trauma and Orthopaedics | Twitter | Urology | Version Jan 2023