Sotalol is a beta-blocker that possessed class III antiarrhythmic properties in high doses.
- Non selective beta-blocker and Class III antiarrhythmic
- Prolongs atrial action potential duration
- Prolongs ventricular action potential duration
Sotalol and AF
- Sotalol is a beta-blocker which possessed class III antiarrythmic properties in high doses. Starting dose is 40 mg bd,
titrated up to 160 mg bd.
- It should be noted that sotalol may cause QT prolongation and should be used with caution.
Although it may be of use in paroxysmal atrial fibrillation, it is not superior to bisoprolol in sustained AF.
- Ventricular arrhythmias/AF/SVT: Oral dose is Sotalol 40 mg bd, titrated up to 160 mg bd.
- Higher doses may be given for VT suppression by specialists
Dose range:You must check with BNF or drug datasheet
|Sotalol||40 mg - 160 mg||BD||PO|
- Monitor for QT prolongation and Torsades de pointes
- Bradycardia, hypotension, bronchospasm, headache, fatigue
- See Beta blockers
- Avoid hypokalaemia and hypomagnesaemia and replace if necessary
- Asthma, bronchospasm or a history of obstructive airways disease.
- 2nd/3rd degree heart blocks, HR < 60/min or SBP < 100 mmHg
- Severe peripheral vascular disease, LVF, Uncontrolled CCF
- Those of beta-blockers e.g. avoid with Verapamil