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MEDICAL DISCLAIMER:The contents are under continuing development and improvements and despite all efforts may contain errors of omission or fact. This is not to be used for the assessment, diagnosis or management of patients. It should not be regarded as medical advice by healthcare workers or laypeople. It is for educational purposes only. Please adhere to your local protocols. Use the BNF for drug information. If you are unwell please seek urgent healthcare advice. If you do not accept this then please do not use the website. Makindo Ltd

Alendronate (Alendronic acid)

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Anaesthetics and Critical Care

Obstetrics Gynaecology

Trauma and Orthopaedics

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Urology

Version Jan 2023

Osteonecrosis of the jaw may be seen in cancer patients (get dental assessment first). Atypical femoral fractures are rare but have been reported with prolonged bisphosphonate treatment for osteoporosis. Review risks and benefits after 5 or more years of use.

About : Always check the BNF link here

Bisphosphonate used for Postmenopausal osteoporosis, Paget's disease, bone metastasis, breast cancer

Action

Reduces osteoclastic bone resorption

Indications and Dose

Osteoporosis
Always take on an empty stomach at least 30 minutes before breakfast or other medicines.
Swallow whole with plenty of water while sitting or standing and remain upright for at least 30min after taking.

Dose range:You must check with BNF or drug datasheet

Name	Starting Dose	Frequency	Route
Alendronic acid	10 mg	OD	PO
Alendronic acid	70 mg	ONCE WEEKLY	PO

Interactions

Risk of ulcers increased with NSAIDs/Aspirin

Contraindications

Achalasia or oesophageal stricture, Oesophageal motility issues
Abnormalities of oesophagus, factors which delay gastric emptying
Hypocalcaemia. Avoid if eGFR less than 35ml/minute/1.73m²

Side effects

Abdominal pain, dyspepsia, constipation, diarrhoea, flatulence,
Oesophageal ulcer, melaena, dysphagia, abdominal distension
Acid regurgitation, musculoskeletal pain, headache
Reduces calcium and phosphate
Rash, Hypersensitivity, Femoral stress fractures
Osteonecrosis of the jaw after tooth extraction

References

Alendronate in BNF

PLEASE NOTE LEGAL ADVICE: The contents are under continuing development and improvements and may contain errors of omission or fact. The official launch will be at the end of 2018. Feedback vital and always welcome at drokane at gmail.com. This is not to be used for the assessment, diagnosis or management of patients. It should not be regarded as medical advice. It is only for educational purposes. Please adhere to your local protocols. If you are unwell please seek healthcare advice from your doctor. This does not replace senior or specialist advice. If you do not accept this then please do not use the website. If you need medical advice, please consult a doctor or other appropriate medical professional. If you are a medical professional and you need advice then speak to your senior or colleagues.

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