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WRITTEN WARNING MUST BE GIVEN to patients prescribed Carbimazole so that they aware to seek help if any signs or symptoms of agranulocytosis - sore throat. Agranulocytosis is dangerous and affects about 0.3 in 1000 patients and should be suspected in patients on high doses presenting with a sore throat, mouth ulcer or any serious infection and the patient is advised to stop the drug and seek medical help. The risk of agranulocytosis is lower with carbimazole than with propylthiouracil. Agranulocytosis is an absolute contraindication to further treatment with antithyroid drugs and treatment with radio-iodine should be given.