|Acute Severe Asthma
|Eosinophilic granulomatosis (Churg Strauss)
|Loffler's syndrome (Pulmonary Eosinophilia)
|Pulmonary Eosinophilia and CXR changes
|Drug Reaction Eosinophilia Systemic Symptoms
The life-threatening potential of DRESS syndrome is high and the mortality is estimated to be around 10% in multiple studies
- Severe idiosyncratic drug reaction with a long latency period.
- Also known as anticonvulsant hypersensitivity syndrome
- Aromatic anticonvulsive drugs (carbamazepine, lamotrigine, phenobarbital)
- Drugs: minocycline, Allopurinol, abacavir, or nevirapine.
- Usually 2- to 6-week latency period for carbamazepine. Allopurinol.
Clinical: Potentially fatal
- Clinical symptoms, anywhere from 2 to 8 weeks after initiating the offending drug
- Fever, rash, urticarial, maculopapular eruption
- Vesicles, bullae, pustules, purpura, target lesions
- Facial oedema, cheilitis, and erythroderma
- SJS/TEN, erythema multiforme
- Hepatitis, pneumonitis, myocarditis, pericarditis, nephritis, and colitis
- Eosinophilia, leukocytosis, and abnormal liver function tests,
- Drug withdrawal, the earlier the better the prognosis.
- Supportive and symptomatic
- Corticosteroids often used, but the evidence is scant
- Ciclosporin may also be required