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Multisystem inflammatory disease caused by the spirochaete Borrelia burgdorferi.
|Stages of Lyme disease|
|Stage 1:||Early localised disease||Spirochetes multiply and spread in the dermis at the site of a tick bite. Usually within 1 month of infection. Pale centre and expanding redness - Erythema migrans. fever, malaise, headache, fatigue and Lymphadenopathy. last 1-3 months|
|Stage 2:||Early disseminated stage||secondary skin lesions, lymphadenopathy, joint pains, myalgia, carditis causing conduction blocks (commoner in US) which are usually temporary not requiring pacing- needs ECG or 24 Hr tape if symptoms, pericarditis, myocarditis, nerve lesions e.g. Unilateral or Bilateral VII palsy which tends to last a few months, lymphocytic meningitis, peripheral neuropathy, radiculopathy|
|Stage 3 :||Late Lyme||Destructive chronic "lyme" arthritis usually of large joints and mild to severe encephalitis and dementia, Acrodermatitis chronica atrophicans commoner in europeans, Neuropathy|