Always watch for a drop in platelets which could be due to Heparin-induced thrombocytopenia (HIT) and thrombosis.
About
Antithrombotics
Unfractionated Heparin
Initial dose of 5000u iv and infusion of 30,000u/24hrs. In older (over 80) or very light patients initial dose of 2500u and infusion of 20,000u given. If unsure seek haematolgical advice. Do discuss with haematologist in pregnant or perioperative patients or those where there is a significant bleeding risk aPTT ratio Action Retest Less than 1.3 times control Bolus dose 5000u and increased infusion by 5000u/24 hrs 6 hrs 1.3-1.4 times control increase by 5000 u /24 hrs 6 hrs 1.5-2.4 times control None 12-24 hrs 2.5-3.0 times control Stop for 30 mins and reduce by 5000u/24 hrs 6 hrs 3.1-4.0 times control Stop for 60 mins and reduce by 5000u/24 hrs 6 hrs 4.1-5 times control Hold for 1 hour and reduce by 7500u/24 hrs 6 hrs Greater than 5 times control Hold for 1 hour and Decrease by 12000u/24 hrs 3 hrs Fractionated : Low molecular weight Heparin
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Anticoagulation and Antithrombotics
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