Caution use for gross haematuria as can clot causing obstruction.
- Used to prevent and limit bleeding
Mode of action
- It is an antifibrinolytic that competitively inhibits the activation of plasminogen to plasmin
- Heavy menstrual bleeding, Prostatectomy and bladder surgery
- Menorrhagia, Conisation of the cervix, Epistaxis, Traumatic hyphaema
- Management of dental extraction in haemophiliacs.
- Hereditary angioneurotic oedema.
- Reduces peri operative need for transfusions with no perceived increase in thromboembolism 
- Traumatic Brain Injury: new data suggests of no benefit, Cardiac surgery
Dose (depends on indication)
- Local Fibrinolysis: Tranexamic Acid 1 g IV TDS
- Menorrhagia: Tranexamic acid 1 g TDS 4 days
- Epistaxis: Tranexamic acid 1 g TDS 7 days
- Parenteral dosing depends on indication: Tranexamic acid 10 mg/kg IV immediately before surgery OR 10 mg/kg IV 6-8 hrly 1 day before surgery
- Acute severe bleeds, trauma patients: Tranexamic acid 1 g IV over 10 min then 1 g slow IV 8 h (CRASH-2 trial).
- Reduce dose in renal failure
- Pregnancy: no known side effects but Tranexamic acid crosses the placenta.
- Prothrombosis is the main worry and concern, seizures
- Gastrointestinal effects, dizziness, fatigue, headache, and hypersensitivity reactions