| Alpha Fetoprotein
| Anti-Hu ab
| Biochemical Lab values
Albumin is a sensitive
but nonspecific measure of protein-calorie malnutrition
- Albumin included in both the liver function test profile and bone profile, and is used to calculate the adjusted calcium level.
- Albumin is the most abundant plasma protein and is synthesised and secreted by the liver.
- High albumin levels seen with dehydration or certain drugs e.g. steroids and insulin.
- Increases in blood proteins will also be caused by prolonged application of a tourniquet.
- Albumin is a protein of 585 amino acids and a molecular weight of 66 kDa
- Encoded by a gene on chromosome 4 and Exclusively synthesized by liver cells
- Release it directly into the bloodstream without storage. Albumin has a half-life of 2 to 3 weeks
- Usually only 20-30% of hepatocytes are committed to the production of 9-12 g of albumin per day
- Liver has a large functional reserve, so that it can increase the synthesis of this protein by 3-4 times
- Serum albumin scarcely crosses the majority of capillaries
Remains in the bloodstream and generates about 70% of the plasma oncotic pressure.
- Albumin is, therefore, the main modulator of fluid distribution throughout body compartments
Decreased albumin levels synthesis by the liver
- Liver disease, Malnutrition, Malabsorption e.g. Crohn's disease
- Acute phase response (the body's physiological response during trauma, burns, infection and inflammation)
- Abnormal excretion or degradation of albumin (for example, due to nephrotic syndrome or haemorrhage).
- For adults, blood taken into a 5mL gold top gel tube (or rust top for the Acute Unit)
- The capacity of albumin to expand the plasma volume