Related Subjects:
|Sedation and Analgesia on ITU
|Neuropathic Pain Management
|Codeine
|Dihydrocodeine
|Diamorphine
|Morphine
|Paracetamol (Acetaminophen)
|Tramadol
|Naloxone (Narcan) Opiate antagonist
Much smaller doses are given to reverse opiate excess in those on palliation as sudden complete reversal may cause severe pain. It is the emergency antidote for overdoses caused by heroin and other opiates or opioids (such as methadone, morphine and fentanyl). The initial dose is usually 0.4-2 mg Naloxone hydrochloride in Adults. Reversal of buprenorphine-induced respiratory depression may be incomplete.
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Mode of action
Indication/Dose (Adults)
Name Starting Dose Frequency Route Naloxone (Opioid toxicity) 400 microgrammes (0.4 mg) stat which may be repeated up to 2-4 mg. larger doses may be given IV Naloxone (opioid toxicity) 400 microgrammes (0.4 mg) stat which may be repeated IM in multiple sites deltoid or anterolateral thigh Naloxone (opioid toxicity in palliation) 100-200 microgrammes (0.1-0.2 mg) stat which may be repeated IV/IM slowly. Full reversal avoided if this would cause severe pain and withdrawal Naloxone (opioid toxicity ) 1.8 mg stat which may be repeated Nasal which may be repeated after 2-3 minutes Cautions
Side effects
References
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Naloxone (Narcan) Opiate antagonist
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