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Related Subjects: |Sedation and Analgesia on ITU |Neuropathic Pain Management |Codeine |Dihydrocodeine |Diamorphine |Morphine |Paracetamol (Acetaminophen) |Tramadol |Naloxone (Narcan) Opiate antagonist
Much smaller doses are given to reverse opiate excess in those on palliation as sudden complete reversal may cause severe pain. It is the emergency antidote for overdoses caused by heroin and other opiates or opioids (such as methadone, morphine and fentanyl). The initial dose is usually 0.4-2 mg Naloxone hydrochloride in Adults. Reversal of buprenorphine-induced respiratory depression may be incomplete.
Name | Starting Dose | Frequency | Route |
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Naloxone (Opioid toxicity) | 400 microgrammes (0.4 mg) | stat which may be repeated up to 2-4 mg. larger doses may be given | IV |
Naloxone (opioid toxicity) | 400 microgrammes (0.4 mg) | stat which may be repeated | IM in multiple sites deltoid or anterolateral thigh |
Naloxone (opioid toxicity in palliation) | 100-200 microgrammes (0.1-0.2 mg) | stat which may be repeated | IV/IM slowly. Full reversal avoided if this would cause severe pain and withdrawal |
Naloxone (opioid toxicity ) | 1.8 mg | stat which may be repeated | Nasal which may be repeated after 2-3 minutes |