Does not cause hypoglycaemia. There is a concern that gliptins can cause acute pancreatitis
- Check BNF or equivalent for UpToDate prescribing advice
Mode of action
- Inhibits dipeptidylpeptidase-4 to increase Insulin secretion and lower glucagon secretion.
- Type 2 diabetes mellitus (with other drugs): Alogliptin 25 mg OD
- Reduce dose to 12.5 mg once eGFR 30-50
- Reduce dose to 6.25 mg once daily if eGFR < 30
- DPP4-inhibitors usually have no effect on weight, and do not cause hypoglycaemia.
- The dose of concomitant sulfonylurea or insulin may need to be reduced to reduce the risk of hypoglycaemia, when used in combination with a gliptin.
- Alogliptin is recommended for first line use, except in patients with renal impairment, when linagliptin is recommended.
Dose range:You must check with BNF or drug datasheet
|Alogliptin ||25 mg||OD||PO|
- Pancreatitis, Severe heart failure
- Abdo pain, GORD, headache, rash