If overdose potentially lethal myelosuppression. The dose regimen for rheumatic disease is 15-25 mg once per week. If you prescribe it daily by accident the patient may die. Advise must seek medical help if any fever, sore throat, bruising, mouth ulcers. Methotrexate toxicity consider folinic acid 15 mg IV OD.
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Indications
Dose
Dose Range (Doses other than weekly for specialist oncology use only)
Name Dose Frequency Route Methotrexate (Rheumatoid disease) 7.5 - 25 mg Once weekly on set day PO Methotrexate (Severe Crohns disease) 10 - 25 mg Once weekly on set day PO Methotrexate (Severe Psoriasis) 2.5 - 25 mg Once weekly on set day PO Interactions
Cautions
Contraindications
Side effects
Toxicity
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Methotrexate
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