FFPs primarily contain stable clotting factors, albumin and Immunoglobulins.
- Fresh Frozen Plasma (FFP) is the liquid part of the blood obtained after separation of the cellular part of the blood.
- The separated liquid part is immediately frozen. FFPs have a volume of 200-300 mL, frozen to a temperature of 25C within 6 hours, to ensure the activity of the coagulation factors.
- FFPs can be stored for upto one year at a temperature of 25C. However, prior to administration, FFPs would be needed to be thawed, and need to be used within 30 minutes of thawing. FFPs primarily contain stable clotting factors, albumin and Immunoglobulins.
- Generally, the dose of FFPs ranges 10-15 mL/kg. That's 1 litre for 70kg adult.
The target INR is 1.7, prothrombin time (PT) <1.5 or an activated Prothrombin time (APTT) of less than twice the normal.
The indications for the transfusion of FFP include the following:
- Presence of laboratory proven coagulopathy with active bleeding.
- Laboratory proven includes PT >1.5, INR >2 and aPTT > twice the normal limit.
- Emergency reversal of Warfarin effect prior to 4 factor PCC, especially if there is a need for urgent surgery or when there is ongoing active bleeding.
- Dilutional coagulopathy having a procedure or in the presence of active bleeding.
- Liver disease with coagulopathy in the presence of active bleeding or needing an intervention.
- Prophylaxis in patients with coagulopathy undergoing surgery or other invasive procedures.
- Replacement of single factor deficiencies namely, factors V and XI.
- Must be compatible blood group i.e. AB universal, O only to O