Related Subjects:
| Acute Porphyrias
| Variegate Porphyria
| Acute Intermittent Porphyria (AIP)
| Porphyria Cutanea Tarda (PCT)
| Porphyria Testing
Acute porphyrias are hereditary disorders of haem biosynthesis; they have a prevalence of about 1 in 75 000 of the population. BNF states that if no safe alternative, drug treatment for serious or life-threatening conditions should not be withheld from patients with acute porphyria.
BNF: Haem arginate is administered by short intravenous infusion as haem replacement in moderate, severe, or unremitting acute porphyria crises. In the United Kingdom the National Acute Porphyria Service (NAPS) provides clinical support and treatment with haem arginate from two centres (Cardiff and Vale University Health Board and King's College Hospital) (see Useful resources).
Drugs to avoid (check all): Diclofenac, Alcohol, OCP, HRT, TCA, Benzodiazepines, Anaesthetic agents (barbiturates, halothane), Antibiotics (cephalosporins, sulfonamides, macrolides, tetracyclines, rifampicin,
trimethoprim, chloramphenicol, metronidazole), Metoclopramide, ACEI, CCB, Statins, Anticonvulsants, Furosemide, Sulfonylureas, Lidocaine, Gold salts, Antihistamines, Amphetamine
About
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Drugs to avoid - See BNF for more
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References
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Acute Porphyrias
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