About : Always check the BNF link here
Mode of action
Dose range:You must check with BNF or drug datasheet
Name Starting Dose Frequency Route Alteplase (PE) Alteplase 10 mg over 2 min
Alteplase 90 mg over 2 h
(Max 1.5 mg/kg for those weighing <65 kg.)
OD PO Alteplase (STEMI within 6 h of symptoms onset Wt < 65 kg) Alteplase 15 mg IV bolus
Alteplase 0.75 mg/kg (max 50 mg) IV over 30 min
Alteplase 0.5 mg/kg (max 35 mg) IV over 60 min.
Max dose 100 mg
OD PO Alteplase (STEMI within 6 h of symptoms onset Wt > 65 kg)
Alteplase 15 mg IV bolus
Alteplase 50 mg IV over 30 min
Alteplase 35 mg IV over 60 min.
OD PO Alteplase (STEMI within 6-12 hrs of symptoms onset Wt > 65 kg)
Alteplase 10 mg IV bolus
Alteplase 50 mg IV over 60 min
Alteplase 10 mg IV over 30 min x 4 (total dose 100 mg over 3 hrs)
OD PO Alteplase (Ischaemic stroke) within 4.5 hrs Alteplase 0.9 mg/kg (max dose 90 mg) with
Alteplase 10% bolus
Alteplase 90% over 60 min.
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