Vasopressin, also called antidiuretic hormone (ADH)= arginine vasopressin (AVP) is as a nonapeptide synthesised in the hypothalamus and is the key regulator of water reabsorption in the distal nephron. In healthy adults, the osmotic threshold for AVP secretion ranges from 280-285 mOsm/kg H2O. Small rises in plasma osmolality of as little as 1% are sufficient to trigger AVP release with proportional increases in urine concentration, and maximal antidiuresis is achieved after increases in plasma osmolality of only 5 to 10 mOsm/kg H2O above the threshold for AVP secretion. Nephron Structure
About
Physiology
Aetiology
Cranial DI (Central DI due to impaired secretion of arginine vasopressin )
Nephrogenic DI (Nephrogenic DI due to impaired action on the collecting tubules)
Clinical
Investigations
Differential of Polyuria
Management
References
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Diabetes Insipidus (Cranial and Nephrogenic)
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