A negative tissue biopsy does not rule out the diagnosis of amyloidosis as it may be patchy except for the heart, where the disease is usually widespread if there are echo changes
About
Aetiology
Different types
Disease Details Primary Amylodiosis (AL) Amyloid Light chain Ig. Myeloma, Waldenstrom's, MGUS, Lymphoma - Cardiac/Renal as above, Periorbital purpura. AL Amyloid results in Restrictive cardiomyopathy and Macroglossia. Development of amyloid in myeloma is associated with a worse prognosis Secondary Amyloidosis (AA) Amyloid Serum Amyloid A protein - Chronic Inflammation e.g. Bronchiectasis, Osteomyelitis, TB, Familial Mediterranean fever and rheumatoid arthritis, TB, Osteomyelitis possibly due to Serum Amyloid A protein and patients develop Nephrotic syndrome Very rarely cardiac/tongue.AA Amyloid very rarely results in Restrictive cardiomyopathy and Macroglossia and these are more typical of AL amyloid Familial (ATTR) Amyloid Transthyretin - Hereditary forms of Amyloid - sensory/autonomic neuropathy with renal/cardiac involvement Beta 2 Microglobulin. Family history of amyloid an neuropathy may suggest ATTR renal dialysis
and carpal tunnel syndrome Clinical Red flags to suggest Systemic Amyloidosis
Investigations
Management
MEDICAL DISCLAIMER:The contents are under continuing development and improvements and despite all efforts may contain errors of omission or fact. This is not to be used for the assessment, diagnosis or management of patients. It should not be regarded as medical advice by healthcare workers or laypeople. It is for educational purposes only. Please adhere to your local protocols. Use the BNF for drug information. If you are unwell please seek urgent healthcare advice. If you do not accept this then please do not use the website. Makindo Ltd |
Systemic Amyloidosis
-
| About | Anaesthetics and Critical Care | Anatomy | Basic Science | Biochemistry | Cardiology | Cases | Clinical Cases | Crib | Dentistry | Dermatology | Differentials | Drugs | ENT | Electrocardiogram | Embryology | Emergency Medicine | Endocrinology | Ethics | Foundation Doctors | Gastroenterology | General Information | General Practice | Genetics | Geriatric Medicine | Guidelines | Haematology | Hepatology | Immunology | Infectious Disease | Infectious Diseases | Infographic | Investigations | Lists | Microbiology | Miscellaneous | Nephrology | Neuroanatomy | Neurology | Nutrition | OSCE | Obstetrics Gynaecology | Oncology | Ophthalmology | Oral Medicine | Paediatrics | Palliative | Pathology | Pharmacology | Physiology | Procedures | Psychiatry | Radiology | Research | Respiratory | Resuscitation | Rheumatology | Statistics | Stroke | Surgery | Surgical | Toxicology | Trauma and Orthopaedics | Twitter | Urology | Version Jan 2023