| Alpha Fetoprotein
| Anti-Hu ab
| Biochemical Lab values
For poorly understood reasons the CRP is of no use as a useful guide of disease activity in Systemic lupus Erythematosus, Scleroderma, Ulcerative colitis and leukaemia
- When first discovered was so named as it reacted with the fraction C polysaccharide of the cell wall of pneumococcus
- Binds to the surface of dead and dying cells and microorganisms to activate the complement system and mark them for phagocytosis.
- Member of the pentraxin family of proteins synthesised in the liver and the Gene is on chromosome 1
- Its likely physiological role is related to complement activity
- CRP is an acute-phase protein that is produced predominantly by hepatocytes
- Production under the influence of cytokines such as interleukin (IL)-6 and TNF alpha
- It has a plasma half-life of 20-40 hours and it may lag clinical findings.
- It is a better general guide than ESR outside the specific illnesses mentioned.
Causes of ↑↑ CRP up to 200 mg/l
- Inflammatory conditions - Infection, Vasculitis
- Connective tissue diseases
- Inflammatory bowel disease
- Others - Malignancy, Trauma, TB
CRP and Atherosclerosis
- Several studies have shown that a raised CRP is associated with a worse prognosis for atherosclerosis.
- These are just minimal elevations above the normal and requires a sensitive test.
- Low < 1 mg /l and Moderate 1-3 mg/l and High > 3 mg /l
CRP in Infection
- Mild inflammation 10–50mg/L
- Active bacterial infection 50–200mg/L
- Severe infection or trauma >200mg/L