| Cause | Clinical Presentation | Investigations | Treatment | 
 | Chronic Hepatitis B | Fatigue, jaundice, anorexia, arthralgia, potential progression to cirrhosis or hepatocellular carcinoma. | HBsAg, HBeAg, HBV DNA, liver function tests (LFTs), liver biopsy or transient elastography (FibroScan) for fibrosis assessment. | Antiviral therapy (e.g., tenofovir, entecavir), regular monitoring for liver disease progression, and liver transplantation in end-stage liver disease. | 
 | Chronic Hepatitis C | Often asymptomatic initially, may progress to fatigue, jaundice, cirrhosis, and hepatocellular carcinoma. | Anti-HCV antibodies, HCV RNA PCR, LFTs, liver biopsy or transient elastography, genotyping of HCV. | Direct-acting antivirals (DAAs) tailored to HCV genotype, monitoring for treatment response, and management of liver complications. | 
 | Autoimmune Hepatitis | Fatigue, jaundice, arthralgia, hepatomegaly, may present with acute liver failure. | Autoantibodies (ANA, SMA, LKM1), immunoglobulins (IgG), LFTs, liver biopsy for histological confirmation. | Corticosteroids (e.g., prednisolone), immunosuppressants (e.g., azathioprine), and monitoring for relapse or progression to cirrhosis. | 
 | Alcoholic Hepatitis | Jaundice, hepatomegaly, ascites, and signs of chronic liver disease in heavy alcohol users. | LFTs (elevated AST:ALT ratio), serum bilirubin, liver biopsy if diagnosis unclear, assessment for alcohol use disorder. | Abstinence from alcohol, nutritional support, corticosteroids in severe cases, liver transplantation in advanced disease. | 
 | Non-Alcoholic Fatty Liver Disease (NAFLD) | Usually asymptomatic, can progress to non-alcoholic steatohepatitis (NASH) with fatigue, hepatomegaly, and cirrhosis. | LFTs, ultrasound, liver biopsy or transient elastography, assessment for metabolic syndrome components. | Lifestyle modifications (weight loss, exercise), management of comorbidities (e.g., diabetes, dyslipidemia), potential use of vitamin E or pioglitazone in selected cases. | 
 | Drug-Induced Hepatitis | Jaundice, fatigue, nausea, potentially asymptomatic; related to medication use (e.g., acetaminophen, isoniazid). | History of drug use, LFTs, exclusion of other causes of hepatitis, liver biopsy if necessary. | Discontinuation of the offending drug, supportive care, monitoring for liver recovery, and avoidance of hepatotoxic drugs in the future. | 
 | Wilson's Disease | Hepatic symptoms (jaundice, hepatomegaly), neurological symptoms (tremor, dysarthria), psychiatric disturbances. | Serum ceruloplasmin, 24-hour urinary copper, liver biopsy with copper quantification, genetic testing for ATP7B mutation. | Copper-chelating agents (e.g., penicillamine), zinc therapy, liver transplantation in cases of liver failure. | 
 | Haemochromatosis | Fatigue, arthralgia, hepatomegaly, skin pigmentation ("bronze diabetes"), diabetes, cardiomyopathy. | Serum ferritin, transferrin saturation, genetic testing for HFE mutation, liver biopsy for iron quantification if diagnosis unclear. | Phlebotomy to reduce iron levels, chelation therapy (e.g., deferoxamine) if phlebotomy is contraindicated, management of complications (e.g., diabetes). |