Related Subjects:
|Metabolic acidosis
|Aspirin or Salicylates toxicity
|Ethylene glycol toxicity
|Renal Tubular Acidosis
|Lactic acidosis
|Tricyclic Antidepressant Toxicity
|Opiate Toxicity
|Carbon monoxide poisoning
|Benzodiazepine Toxicity
|Paracetamol (Acetaminophen) toxicity
|Amphetamine toxicity
|Beta Blocker toxicity
|Calcium channel blockers toxicity
|Cannabis toxicity
|Cyanide toxicity
|Digoxin Toxicity
|Ecstasy toxicity
Many of these agents may also cause coma or delirium and so clinical signs may assist when history is unavailable
Clinical assessment Possible cause Pink rosy colour Cyanide, carbon monoxide Nausea, vomiting Paracetamol overdose, opiates, NSAIDs, Iron toxicity, Salicylates. Small pupils Opiates (Coma small pupils), Gamma hydroxybutyrate, Pontine bleed from cocaine, Cholinergic syndrome (Insecticides). Large pupils Cocaine, Tricyclic antidepressants, Amphetamines, Anticholinergic syndrome - Atropine, 'Belladonna'. Severe hypertension Cocaine, amphetamines. Bradycardia Digoxin, Beta Blockers, Calcium channel blockers, opioids. Hypoglycaemia Insulin, Sulphonylureas, Alcohol, Quinine, Salicylates. Hyperglycaemia Organophosphates, Theophyllines, MAOIs Hyperventilation Salicylates Renal failure Renal failure, Salicylates, paraquat, ethylene glycol. Hyperthermia Serotonin syndrome, Cocaine, ecstasy, MAOIs, Theophylline. Hypothermia Exposure, phenothiazines, barbiturates RUQ pain/Jaundice Paracetamol poisoning, Organic solvents. Abdominal pain Iron poisoning, lead toxicity, NSAIDs. Seizures Mefenamic acid, TCAs, Opioids, Theophylline, Cocaine, Alcohol. Rhabdomyolysis Amphetamines. Myoclonic jerks GHB, GBL. Chest pain Cocaine, Carbon monoxide Oral ulcers Corrosives, paraquat Elevated osmolar gap Acetone, Mannitol, methanol, Acetone, ethanol, ethylene glycol. Anion gap metabolic acidosis Methanol, metformin, renal failure, Diabetic/Alcoholic Ketoacidosis, Iron, isoniazid, Lactic acidosis, Ethylene glycol, cyanide, carbon monoxide, toluene, Salicylates Hits
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Drug Toxicity - clinical assessment
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