Rare but important causes of acquired heterochromia are neuroblastoma seen in childhood and melanoma usually in later life with a dark spot on the iris
- Heterochromia is when a person has different coloured eyes or eyes that have more than one colour.
- Usually, no significance but is seen in a few conditions.
- Commoner in animals.
Causes of heterochromia in infants can include
- Benign heterochromia
- Horner’s syndrome
- Sturge-Weber syndrome
- Waardenburg syndrome
- Hirschsprung disease
- Bloch-Sulzberger syndrome
- von Recklinghausen disease
- Bourneville disease
- Parry-Romberg syndrome
Causes of acquired heterochromia include:
- Eye injury
- Bleeding in the eye
- Swelling, due to iritis or uveitis
- Eye surgery
- Fuchs' heterochromic cyclitis
- Acquired Horner’s syndrome
- Glaucoma and some medications used to treat it
- Latisse, a repurposed glaucoma medication used cosmetically to thicken eyelashes
- Pigment dispersion syndrome
- Ocular melanosis
- Melanoma - dark spot on iris
- Posner-Schlossman syndrome
- Iris ectropion syndrome
- Benign and malignant tumors of the iris
- Diabetes mellitus
- Central retinal vein occlusion
- Chediak-Higashi syndrome
- At birth consult with paediatrician. It may be normal changes of eye pigment and entirely benign. May need to see ophthalmologist.
- Later in life consider Ophthalmological opinion. Can be due to an eye injury.