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Related Subjects: |Adrenal Adenomas |Adrenal Cancer
Cause | Clinical Features | Investigations | Management |
---|---|---|---|
Polycystic Ovary Syndrome (PCOS) | Irregular menstruation, acne, obesity, insulin resistance, infertility | Serum testosterone, LH/FSH ratio, pelvic ultrasound | Weight loss, oral contraceptives, anti-androgens (e.g., spironolactone), metformin |
Congenital Adrenal Hyperplasia (CAH) | Virilization, ambiguous genitalia in newborns, early pubarche, acne | 17-hydroxyprogesterone levels, ACTH stimulation test | Glucocorticoid therapy, mineralocorticoid replacement if necessary |
Cushing's Syndrome | Moon face, central obesity, purple striae, muscle weakness, hypertension | 24-hour urinary free cortisol, dexamethasone suppression test, serum ACTH | Surgical removal of adrenal or pituitary tumour, radiation, cortisol-lowering medications |
Androgen-Secreting Tumours | Rapid onset of hirsutism, virilization, menstrual irregularities | Serum testosterone, DHEA-S levels, imaging studies (CT/MRI) | Surgical removal of the tumour, possible chaemotherapy or radiotherapy |
Idiopathic Hirsutism | Excessive hair growth without other clinical signs, normal menstruation | Normal hormone levels, exclusion of other causes | Cosmetic hair removal (laser, electrolysis), anti-androgens (e.g., spironolactone) |
Medications (e.g., Anabolic Steroids, Phenytoin) | Hirsutism, possibly other signs depending on the specific medication | Review of medication history, serum testosterone levels | Discontinuation of offending medication, alternative drugs, cosmetic treatment |
Acromegaly | Coarsening of facial features, enlarged hands and feet, joint pain | Serum IGF-1, glucose tolerance test, MRI of the pituitary gland | Surgical removal of pituitary adenoma, medication (somatostatin analogs), radiation therapy |