There are several mechanisms through which drugs can cause patterns of liver damage. The liver problems may just be a slight increase in transaminases which requires no action or acute liver failure. They rarely cause chronic disease. Cholestasis Chlorpromazine causes a hypersensitivity reaction and occurs with 1% of patients within 4 weeks of starting drug, High dose OCP Mixed hepatic/cholestatic hepatitis NSAIDs, Co-Amoxiclav, Statins Acute hepatitis Anti-tuberculous e.g. Isoniazid and rifampicin, Paracetamol overdose, Methyldopa, Atenolol, Halothane NASH Amiodarone, Tamoxifen, Tetracyclines, Sodium Valproate Venous obstruction Busulphan, Azathioprine Fibrosis most notably Methotrexate
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Drug induced liver disease
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