ABC Medical Notes.com
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Smokers need higher dose; elderly or CCF smaller dose. Ensure correct brand is used as there are different formulations with different bioavailabilities. Complex interactions. Always check with existing drugs.
|Aminophylline Oral||225-450 mg BD for non smokers||OD||PO|
|Aminophylline Oral||350-700 mg BD for smokers||BD||PO|
|Aminophylline loading dose IVl||5 mg/kg (250-500 mg) if not on drug already||Once||IV over 1 hour|
|Aminophylline Maintenance dose IV||500-750 mg over 24 hrs Aim for serum levels of 10-20 mg/L Wait until 4-6 h after infusion started. Stop infusion and wait 15 min and then take level.||Infusion||IV over 4 hr|