There is a 10-fold intersubject variability in response to a given dose of Heparin; hence with full-dose Heparin therapy its coagulation effect (APTT ratio) must be monitored at least daily and the dose adjusted to achieve the target therapeutic range, within which the risks of bleeding and thrombosis are each minimised
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Properties
Indications
Cautions
Monitoring
Side effects
Dose (UFH)
APTT Heparin sodium 1000 U/ml >5.0 stop for 2 h; reduce by 0.5 ml/h (500 U) and recheck at 4 h
4.1-5 stop for 1 h; reduce by 0.3 ml/h (300 U) and recheck at 4 h
3.6-4 reduce by 0.2 ml/h (200 U)
3.1-3.5 reduce by 0.1 ml/h (100 U)
2.0-3.0 NO CHANGE
1.5-1.9 increase by 0.1 ml/h (100 U)
1.2-1.4 increase by 0.2 ml/h (200 U)
<1.2 give 2500 U IV bolus; increase by 0.4 ml/h (400 U)
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Heparin - Unfractionated Heparin
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