Opioid Drug Dose Comments: Provides analgesia and some sedation
Morphine 1 mg/ml and give at 1-10 ml/hr in Normal saline Familiar drug. Cheap and reliable. half life is long and so takes time to wear off. Onset can be slow up to 30 minutes
Fentanyl 50 mcg/ml and give at 1-10 ml/hr in Normal saline Rapid onset. Can build up.
Alfentanil 500 mcg/ml and give at 1-10 ml/hr in Normal saline Instant onset and rapid offset once stopped.
Remifantanil 100 mcg/ml and give at 1-10 ml/hr in Normal saline Short acting. Expensive. Respiratory depressant
Drug Dose Comments: Provides deep sedation
Propofol Neat as 1% 10 mg/ml at 1-30 ml/hr or 2% 20 mg/ml at 1-20ml/hr Can cause hypotension in large doses and respiratory depression. Rapid onset. can provide instant sedation of combative patients. Quick offset. Metabolic acidosis if prolonged use. Raised lipids and LFTs.
Midazolam 1 mg/ml at 1-20 ml/hr Slow offset. Accumulates in renal failure
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Sedation and Analgesia on ITU
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