Two main roles - (1) the substrate for fibrin formation and (2) the ligand for the platelet aIIβIII receptor, which promotes platelet aggregation.
- Fibrinogen is Factor I found in high concentrations in plasma
- Is converted to fibrin, which stabilizes blood clots and promotes hemostasis.
- Contributes to thrombosis, host defense, inflammation, and wound healin
- Encoded by three genes: Aa (FGA), BBeta (FGB), and ? (FGG) on chromosome 4.
- Glycoprotein molecule produced in the liver
- Supports platelet aggregation
- Basal and inducible secretion
- Fibrinogen converted to Fibrin by thrombin,
- Low level leeds to bleeding
- Normal amount 2-4g/L
- Consumption :DIC and thrombosis
- Congenital decreases in fibrinogen
- Afibrinogenaemia: no fibrinogen produced at all.
- Hypofibrinogenaemia : reduced amounts of fibrinogen are produced by the body, which can cause mild, moderate or severe bleeding, depending on the amount of fibrinogen present.
- Dysfibrinogenaemia: this is where the amount of fibrinogen produced is normal but it does not work properly.
- Contained in fresh frozen plasma (FFP) and cryoprecipitate (typically 10 units).
- Target is usually ≥ 1 g/L
- Fibrinogen may be given as a medication from BNF