There is some evidence that it may reduce efficacy of Clopidogrel. Remains under review. Always ensure dyspepsia, not due to gastric/oesophageal cancer
- Some potentially significant interactions
- Effective acid suppression
- Inhibits H+/K+ ATPase pump on parietal cell membrane
- Secretes H+ into the gastric lumen
- Markedly reduces acid secretion
- PUD, Oesophagitis : Omeprazole PO 10-40 mg once daily
- Upper GI bleed: 80mg Omeprazole in 250ml Sodium Chloride 0.9% or 5% Glucose over 60 mins and then 80 mg in 250ml Sodium Chloride 0.9% over 10 hrs for a total of 72 hours. A total of 7 bags will be given. Bags should be prepared immediately before administration. A total of 16 vials of 40mg Omeprazole will be needed for the complete infusion.
- Duodenal ulcer : Omeprazole 20 mg once daily. Most patients heal within four weeks
- Gastric Ulcer: Omeprazole 40 mg once daily for 4-8 weeks
- GORD: Omeprazole 20 mg daily for 4 to 8 weeks.
- Zollinger-Eillison syndrome : Omeprazole starting dose is 60-120 mg /d.
- Omeprazole acts as an inhibitor of CYP 2C19
- Potential toxicity of diazepam, Warfarin and phenytoin
- May reduce activity of Clopidogrel
- Interferes with antiretrovirals
- May increase the serum levels of tacrolimus.
- Exclude gastro-oesophageal cancer
- Reduce dose in liver failure to 20mg/day
- Mild and uncommon, Diarrhoea, rashes, headaches, arthralgia