Pre-dose ('trough') concentration should be 10-15 mg/L (15-20 mg/L for severe infections). Give slowly to avoid 'Red Man Syndrome. Red man syndrome is related to the rate of administration. It is common when vancomycin is administered at a rate of 1g in 2 hrs. The rate of infusion must not exceed 10mg/min. Max dose is 4g/day
About: Always check the BNF link here
Action
Indications
Administration
Dose range: You must check with BNF or drug datasheet
Name Starting Dose Frequency Route Vancomycin (infection) 15-20 mg/kg every 8-12 hrs(max. per dose 2 g). In Severe infections Loading dose of 25-30 mg/kg may be given. Adjust to plasma-concentration monitoring. 8-12 hours IV Vancomycin (C. difficile first infection or recurrence) 125 mg 6-hourly PO for 10-14 days Vancomycin (Severe C Diff) 500 mg 6-hourly PO/NG or rectal with IV Metronidazole Admin and Monitoring Intermittent dosing
Maintenance Dosing intervals and doses using creatinine clearance
Dose Adjustments
Interactions
Cautions
Contraindications
Side effects
Reference
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Vancomycin
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