Vinblastine should not be given intramuscularly, subcutaneously or intrathecally. For intravenous use only. Fatal if given by other routes
- Vinblastine is a vinca alkaloid and a chemical analogue of vincristine.
Mode of action
- Cytotoxic drug that arrests cell growth at the metaphase
- It binds to tubulin and halts mitosis
- Hodgkin's disease; non-Hodgkin's lymphoma
- Carcinoma of the breast; methotrexate-resistant choriocarcinoma
- Renal cell carcinoma; testicular teratoma and seminoma; histiocytosis X.
- For intravenous use only. Fatal if given by other routes
- Should not be given intramuscularly, subcutaneously or intrathecally.
- The drug should not be used in pregnant women unless the expected benefit outweighs the potential risk.
- Advise patient to seek help if your temperature goes over 37.5°C (99.5°F) or over 38°C (100.4°F), depending on the advice given by your chemotherapy team you suddenly feel unwell, even with a normal temperature you have symptoms of an infection - this can include feeling shaky, a sore throat, a cough, diarrhoea or needing to pass urine a lot.
- Low WCC, active infection
Side effects: Peripheral neuropathy, constipation, jaw pain, ileus
- Nausea, vomiting, diarrhoea, alopecia
- Peripheral neuropathy, Low Hb, WCC and platelets
- Infection and marrow suppession
- Vestibular and auditory damage to the eighth cranial nerve.