Related Subjects:
|Microangiopathic Haemolytic anaemia
|Haemolytic anaemia
|Immune(Idiopathic) Thrombocytopenic Purpura (ITP)
|Thrombotic Thrombocytopenic purpura (TTP)
|Haemolytic Uraemic syndrome (HUS)
|Thrombocytopenia
|Disseminated Intravascular Coagulation (DIC)
Due to a deficiency in the metalloproteinase ADAMTS13, which is involved in the regulation of von Willebrand factor. Patients with TTP require specialist care, in a regional centre. It carries a 90% mortality rate if incorrectly treated
TTP has 5 distinct features - the Pentad
Aetiology
Causes
Clinical
Investigations
Differential TTP vs HUS vs Meningococcal septicaemia vs DIC
Differential
Management: urgent Haematology consult
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Thrombotic Thrombocytopenic purpura (TTP)
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