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Related Subjects: | Chronic liver disease | Cirrhosis | Alkaline phosphatase (ALP) | Liver Function Tests | Ascites Assessment and Management | Budd-Chiari syndrome | Autoimmune Hepatitis | Primary Biliary Cirrhosis | Primary Sclerosing Cholangitis | Wilson disease | Hereditary Haemochromatosis | Alpha-1 Antitrypsin (AAT) deficiency | Non alcoholic steatohepatitis (NASH) | Spontaneous Bacterial Peritonitis | Alcoholism and Alcoholic Liver Disease
These are not tests of liver function but liver damage or cholestasis. Normal LFTs does not mean a normal liver. The three main causes of an acute and severe derangement of all liver enzymes are hepatic ischaemia, viruses or drugs/toxins
Liver Disease | Abnormal test | Diagnostic test |
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Autoimmune hepatitis | Elevated AST and ALT | ANA anti-smooth muscle ab |
Primary biliary cirrhosis | Elevated ALP | Antimitochondrial antibody |
Alcoholic liver disease | AST/ALT >2 | Improves with abstention |
Primary sclerosing cholangitis | Raised ALP | MRCP pANCA |
Haemochromatosis | Elevated AST and ALT | Ferritin, Genetic Analysis |
Alpha-2 antitrypsin | Elevated AST and ALT | Phenotype analysis |
Wilson's disease | Elevated AST and ALT | ALP low, Ceruloplasmin low, High urine copper, High liver copper |
Hepatitis A | Elevated AST and ALT | Anti HAV IgM |
Hepatitis B | Elevated AST and ALT | HbSAg, Anti HBc IgM, HbeAg, HBVDNA |
Hepatitis C | Elevated AST and ALT | Anti HCV, HCV RNA |