As high doses of diethylstilbestrol in early pregnancy have caused vaginal carcinoma in
female offspring 16-20 years later, it should not be used in pre-menopausal women.
- Included for historical reasons
- Due to its carcinogenic potential, now only used to treat malignant disease.
Mode of action
- Reduces testosterone levels in the management of
androgen-dependent carcinomas such as prostate and some post-menopausal carcinomas such as breast cancer in females
- Management of prostatic carcinoma: 1 - 3 mg daily.
- Management of post-menopausal breast carcinoma: 10 - 20 mg daily.
- Pregnancy, children
- Oestrogen dependent tumours - breast, endometrium
- Undiagnosed vaginal bleeding, porphyria
- moderate to severe hypertension
- Severe or active liver disease
- Dyslipidaemia, MI, Stroke, VTE
- Sickle cell anaemia, untreated polycythaemia and
- Vaginal or Cervical cancer in female offspring in teenage years of used in pregnancy