Related Subjects:
| Ferritin
| CEA
| ESR
| CRP
| ALP
| LDH
| HbA1c
| Alpha Fetoprotein
| Neutrophil Alkaline Phosphatase
| Anti-Hu ab
| Anti-Yo ab
| Anti-SCL70 ab
| Prolactin
| Liver Function Tests
| Biochemical Lab values
| Rheumatology Autoantibodies
Autoantibody Disease
Rheumatoid factor (RF) Antibodies directed at the Fc fragment of IgG and can be IgM, IgG or IgA. Routinely we look for IgM. They are found in 75% of RA disease. Found in 100% of RA with extraarticular manifestations. Seen in 5% of a normal population. These suggest more severe arthritis. Also seen in SLE, Sjogren's, Systemic sclerosis, Dermatomyositis. Cryoglobulinaemia, leprosy, bacterial endocarditis, hepatitis C, sarcoidosis, malignancy, chronic liver disease
Anti-cyclic peptide (ACPA) 70% of Rheumatoid arthritis. More specific than RF. Can be present for years before diagnosis. Suggest more severe disease. Can be seen in SLE and Sjogren's. Also autoimmune hepatitis type 1.
Antinuclear antibodies Non-specific – autoimmune disease, infections, normal individuals
Anti-topoisomerase I (Scl-70) Diffuse cutaneous SSc
Anti Jo-1 Polymyositis and Dermatomyositis
Anti-centromeric Limited SS
Anti-RNA polymerase antibodies I and III Systemic sclerosis
Cytoplasmic ANCA Granulomatosis with polyangiitis (Wegener’s granulomatosis)
Perinuclear ANCA Microscopic polyarteritis, eosinophilic granulomatosis with polyangiitis (formerly known as Churg–Strauss syndrome)
IgG anti-dsDNA SLE
Anti-histone Drug-induced lupus
Anti-Ro (SS-A) Primary SS, SLE
Anti-La (SS-B) Primary SS, SLE
Beta2-glycoprotein 1 Antiphospholipid syndrome
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Rheumatology Autoantibodies
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