If a patient does not respond to one 5HT1-receptor agonist, an alternative 5HT1-receptor agonist should be tried
Mode of action
- Acute migraine; cluster headache: Sumatriptan 50-100 mg; dose may be repeated after at least 2 hours if migraine recurs; max. 300 mg in 24 hours.
- Parenterally: It can also be given as Sumatriptan 6 mg SC and the dose may be repeated after at least 1 hour if headache recurs; max. 12 mg in 24 hours
- 5HT1-receptor agonists are not indicated for the treatment of hemiplegic, basilar, or ophthalmoplegic migraine.
|Sumatriptan ||50-100 mg Max 300 mg/day||PO|
|Sumatriptan||6 mg max. 12 mg in 24 hours
|Sumatriptan||11-20 mg 40 mg in 24 hours
- Ischaemic heart disease, previous myocardial infarction
- Coronary vasospasm (including Prinzmetal's angina)
- Uncontrolled or severe hypertension.
- Tingling, heat, heaviness, pressure, or tightness of any part of the body
- Anaphylaxis, flushing, dizziness, the feeling of weakness; fatigue
- Nausea and vomiting also reported.