Makindo Medical Notes.com

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• During development, retinal vessels grow from the optic disc towards the ora serrata (the peripheral retina).
• Blood vessels reach the nasal ora serrata at 36 weeks and the temporal ora serrata at 40 weeks.
• ROP is the result of arrest of vessel growth and rarely occurs before 32 weeks.

Aetiology

• Arrest of normal vascular development:
• Hyperoxia, often iatrogenic as treatment of neonatal respiratory distress syndrome.
• Arrest of normal growth factor production in the retina.
• Lack of retinal vascular development.o Hypoxia ensues:
• As the developing retina becomes more metabolically active, hypoxia ensues.
• This stimulates the growth of abnormal blood vessels, leading to retinal detachment.
• Other risk factors include birth weight < 1500g, extreme prematurity (<28 weeks), and neonatal hyperglycaemia.

Clinical: Exam may show

• White demarcation separating vascular and avascular areas
• Partial or complete retinal detachment, with or without foveal involvement.
• Abnormal tortuous retinal vessels may be visualised.

Screening and Investigations

• High risk children, born at less than 32 weeks or weighing < 1500g, should be screened for the development of ROP by an ophthalmologist.
• There are specific guidelines for how often children should be screened and at how many weeks after birth depending on the severity of disease and the degree of prematurity.

Management

• Careful control of oxygenation in prematurity is essential in the prevention of ROP.
• Anti-VEGF agents can help to prevent the development of abnormal blood vessels.
• Transpupillary diode laser can be used to ablate the abnormal blood vessels and reduce the risk of retinal detachment.
• The non-vascularised retina can be sacrificed with ablative laser to prevent progression.

Prognosis

• In severe cases, blindness is often inevitable, particularly if retinal detachment occurs.
• Some vision may be preserved in milder cases, particularly if abnormal vessel growth does not occur or is arrested early.

References and Further Reading

• Retinopathy of Prematurity, Hellstrom et al., The Lancet, 2013; 382, 9902: 1445-1457.
• EyeWiki